Xenograft Tumor Models

        The following are the main considerations in assessing the validity of animal models of ovarian cancer: 

        Structural validity: The pathogenesis of animal disease models should have homology or similarity with human diseases. 

        Predictive validity: Animal disease models should have predictability in drug treatment, and relevant drugs can demonstrate therapeutic effects on animal disease models. 

        Experimental animal species, age, modeling methods, detection indexes, etc.: For example, female BALB/c mice are often used to establish ovarian cancer animal models, and most of them are selected at 4-6 weeks and 6-8 weeks of age; the most common method of modeling is ectopic transplantation, which is often inoculated subcutaneously in the axilla; in the use of animal models for ovarian cancer, transplantation models are the most commonly used, with heterotopic transplantation being much more commonly used than orthotopic transplantation; the cell lines or ovarian cancer tissues used are mostly of human origin. 

        A good animal disease model is one that can meet these validity criteria. On the basis of meeting these validity requirements, if it can also have the characteristics of simplicity, high reproducibility, and economy, it is an excellent animal model that can be widely used.