Xenograft Tumor Models

Cell name：

SW480

Other names for the model：

SW-480、SW 480、SW480E

Cell information：

SW480 cells are derived from human colon adenocarcinoma cells. The cells are CSap and rectal antigen 3 negative; keratin positive; the G→A mutation at codon 273 of the p53 gene causes Arg→His substitution at codon 309. C→T mutation leads to Pro→Ser substitution; cellular p53 protein expression levels increase; the expression of oncogenes c-myc, K-ras, H-ras, N-ras, myb, sis and fos is positive. Click to view More Information.

Model information：

1X10⁷  SW480 cells per mouse are mixed with Matri-gel and inoculated into right flank region in NOD SCID mice.

About 9 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 49 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).