Xenograft Tumor Models

Cell name：

A375

Other names for the model：

A 375、A-375、A375-MEL、A375-mel、A375mel

Cell information：

A375 cells are human melanoma cells that express immune checkpoint proteins such as PD-L1, PD-L2, and OX40L. Click to view More information.

Model information：

5X10⁶  A375 cells per mouse are mixed with Matri-gel and inoculated into right flank region in BALB/c Nude mice.

About 5 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 26 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).