Successful drug development is inseparable from an understanding of basic biology and disease biology. With the advancement of tumor biology, bioinformatics, and multi-omics, scientists have deepened their understanding of disease biology and discovered more potential targets. Types of targets include kinases, proteases, phosphatases, protein-protein interactions, and key proteins previously thought to be undruggable. To develop new drug molecules targeting the key proteins, it is necessary to establish in vitro biological analysis methods to evaluate and screen compounds. Robust, reliable biological assays are critical to advancing a project from an early proof-of-concept to a candidate molecule. As a project may last for several years, the biological method needs to be developed, optimized and validated in order to ensure that the relevant biological analytical method produces accurate and comparable results in the different phases of the project.
