Xenograft Tumor Models

        Animal models of osteosarcoma are mainly used to study the occurrence, development, and treatment of osteosarcoma, which are  mainly divided into the following types: 

        Radionuclide induced model: inducing osteosarcoma in animals through radionuclide. 

        Chemical induction model: Using specific chemical substances, such as DMBA, to induce the production of osteosarcoma in animals. 

        Biological oncogenic factor induction model: inducing osteosarcoma in animals through biological oncogenic factors, such as specific gene mutations. 

        Xenograft model: Transplanting human osteosarcoma cells or tissues into animal bodies, such as nude mice. Transgenic mouse model: Through genetic engineering technology, specific genes in mice are altered to induce the occurrence of osteosarcoma. 

        The most widely used model currently is xenograft model.