Xenograft Tumor Models

        There are two main types of xenograft model of kidney cancer: Cell-Derived Xenografts model and Patient-Derived Xenografts model. 

        The CDX model involves inoculating tumor cell lines subcutaneously, intravenously, or orthotopically into immunodeficient animals or humanized immune system mice to form subcutaneous or orthotopic tumor models. With the advantages of short experimental period, high modeling success rate and relatively low experimental cost, CDX model is a widely used in vivo tumor function model for carrying out drug target validation, pharmacodynamic evaluation, PK/PD study and multidrug synergistic pharmacodynamic evaluation. 

        The PDX model is a transplanted tumor model formed by implanting tumor tissue and primary cells from patients into immunodeficient mice. This model preserves the growth microenvironment of parental tumors as much as possible, which is conducive to better expressing the characteristics of parental tumors and maintaining tumor heterogeneity.