Syngeneic Tumor Models

        Animal models of lung cancer are important tools for in-depth research on lung cancer.Existing lung cancer models are divided into two main categories: 

        Models that induce epithelial transformation: these models are achieved by altering the expression of oncogenes or oncogenes suppressors using chemical carcinogens or genetic engineering. 

        Transplantation models of lung cancer cell lines or patient tumor tissues: these models utilize murine-derived lung cancer cell lines (CDX) or patient tumor tissues (PDX) for ectopic or orthotopic delivery. 

        Among them, CDX model and PDX model are the most widely used animal models of lung cancer. 

        CDX model: it is mainly a tumor model constructed by transplanting tumor cell lines into nude mice or NSG mice. The advantages of this model are good stability, short cycle, and economy, but due to the fact that tumor cell lines are artificially purified and cultured for multiple generations, the CDX model constructed cannot maintain the heterogeneity of tumor tissues. 

        PDX model: the tumor tissue is directly transplanted into NSG mice, which maintains the heterogeneity of the tumor, and its biological characteristics are more completely maintained, with a higher degree of clinical similarity.