Syngeneic Tumor Models

Cell name：

Renca

Cell information：

Renca cells are derived from kidney tumors spontaneously formed in BALB/c mice, and are poorly differentiated renal cortical adenocarcinoma. They are granular, pleomorphic, and have a large nucleus.

Model information：

3X10⁵  Renca cells per mouse are inoculated into right flank region in BALB/c mice.

About 8 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 15 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).

Reactivity to tumor immune drugs ：

Responsive to multiple immune checkpoint inhibitors or activators

Application areas：

Pharmacodynamic evaluation of immune checkpoint inhibitors or activators and combinations