Syngeneic Tumor Models

Cell name：

MC-38

Other names for the model：

MCA-38、MCA 38、MCA38、Mouse Colon 38、Murine Carcinoma-38、Colon 38、Colon-38、Colon38、C38

Cell information：

MC-38 cells originate from C57BL/6 mice and are induced by 1,2-dimethylhydrazine dihydrochloride (DMH) to form colon cancer cells

Model information：

The MC-38 transplanted tumor inoculated in C57BL/6 mice has strong immunogenicity and can cause a strong immune response. Therefore, it is often used in the study of immune checkpoint inhibitors and related combination drugs. In addition, as this model can cause cachexia, it is also commonly used as a model for studying cachexia.

Reactivity to tumor immune drugs ：

There was a moderate response to anti-mouse PD-1 antibodies and anti-mouse PD-L1 antibodies; a weak response to mCTLA-4 antibodies

Application areas：

Pharmacodynamic evaluation of immune checkpoint inhibitors and combinations