Syngeneic Tumor Models

Cell name：

B16-F10

Other names for the model：

B16/F10、B16 F10、B16F10、B16 melanoma F10

Cell information：

B16F10 cells are melanoma cells derived from C57BL/6J mice. They are a subclone of B16 cells that were passaged in C57BL/6 mice 10 times

Model information：

B16F10 transplanted tumors inoculated in C57BL/6J mice are prone to metastasis. Compared with other models (such as Renca, CT26, EMT6, etc.), there are fewer macrophages and complement systems in B16F10 transplanted tumors, and the expression levels of natural immune related genes such as TLR4, CD14, Ticam1, and TLR5 are lower

Reactivity to tumor immune drugs ：

Responsive to multiple immune checkpoint inhibitors or activators

Application areas：

Pharmacodynamic evaluation of combination drugs related to immune checkpoint inhibitors