Syngeneic Tumor Models

Cell name：

B16-F10

Other names for the model：

B16/F10、B16 F10、B16F10、B16 melanoma F10

Cell information：

B16F10 cells are melanoma cells derived from C57BL/6J mice. They are a subclone of B16 cells that were passaged in C57BL/6 mice 10 times

Model information：

2X10⁵  B16-F10 cells per mouse are inoculated into right flank region in C57BL/6J mice.

About 8 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 9 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).

Reactivity to tumor immune drugs ：

Responsive to multiple immune checkpoint inhibitors or activators

Application areas：

Pharmacodynamic evaluation of combination drugs related to immune checkpoint inhibitors