Syngeneic Tumor Models

        Melanoma is a malignant tumor of melanocytes originating from the neural crest, ranking the third among skin malignancies. Compared with other malignant tumors, the overall success rate of melanoma treatment is still one of the worst. Animal models are important tools for studying their pathogenesis, prevention, treatment plans, and identifying potential therapeutic targets and biomarkers. 

        Melanoma mouse animal models can be divided into inducible models, transplanted models, and transgenic models. 

        The transplanted model is currently the most widely used tumor model. The transplanted melanoma mouse model summarizes some characteristics of melanoma orthotopic development and metastasis, and is often used for evaluating anti-tumor and metastatic drugs. 

        Overall, the melanoma mouse model is an important tool for melanoma research,but due to differences in the genome, gene regulation, cell type, organ structure and composition between experimental animals and humans, the ability of these models to predict the clinical efficacy of drug therapy is limited.Therefore, it is necessary to consider the characteristics, scope of application, and research objectives of various animal models in order to select and establish ideal animal models.