Syngeneic Tumor Models

Cell name：

Hepa1-6

Cell information：

Hepa1-6 cells are derived from liver tumors of C57L/J mice. Unlike other commonly used mouse liver tumor cells, Hepa1-6 cells are derived from spontaneously formed liver tumors rather than tumors induced by compounds.

Model information：

5X10⁶  Hepa1-6 cells per mouse are mixed with Matri-gel and inoculated into right flank region in C57BL/6J mice.

About 4 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 22 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).

Reactivity to tumor immune drugs ：

Moderate response to multiple immune checkpoint inhibitors

Application areas：

Pharmacodynamic evaluation of multiple immune checkpoint inhibitors alone and in combination