Syngeneic Tumor Models

Cell name：

4T-1

Other names for the model：

4T1-A、4T1.0、4T1/WT

Cell information：

4T-1 cells are mouse mammary epithelial tumor cells that are highly susceptible to tumor formation and metastasis in mice.

Model information：

The growth and metastasis of 4T-1 transplanted tumor inoculated in BALB/c mice are very similar to human breast cancer (stage IV), which is often used as a model to simulate triple negative breast cancer 4T-1 transplanted tumors can be subcutaneously or orthotopic injected into the breast, but the tumor growth rate and volume of breast in situ injection are higher than those of subcutaneous injection

Reactivity to tumor immune drugs ：

Not sensitive to anti-mouse PD-1 antibody; not sensitive to mPD-L1 + CTLA4 antibody

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Application areas：

Tumor metastasis, circulating tumor cell research, tumor microenvironment regulation (such as the effect of HA on tumor growth), etc.