Syngeneic Tumor Models

Cell name：

4T-1

Other names for the model：

4T1-A、4T1.0、4T1/WT

Cell information：

4T-1 cells are mouse mammary epithelial tumor cells that are highly susceptible to tumor formation and metastasis in mice.

Model information：

3X10⁵  4T-1 cells per mouse are inoculated into right flank region in BALB/c mice.

About 6 days post inoculation, the mice can be grouped, with average tumor volumes at 150-250 m³.

The duration of treatment is about 24 days post grouping (when the tumor volumes in the vehicle group reach 2000 m³).

Reactivity to tumor immune drugs ：

Not sensitive to anti-mouse PD-1 antibody; not sensitive to mPD-L1 + CTLA4 antibody;

Application areas：

Tumor metastasis, circulating tumor cell research, tumor microenvironment regulation (such as the effect of HA on tumor growth), etc.