In Vivo PK

       Cassette PK experiment refers to the simultaneous evaluation of PK properties of two or more drugs in the same experiment. This type of experiment is commonly used to evaluate drug interactions and the impact of drug combination on PK parameters.  

       In Cassette PK experiments, researchers will administer two or more drugs to experimental animals simultaneously or separately, and collect blood or tissue samples at different time points to determine the concentration of various drugs. Based on these data, researchers can calculate the absorption, distribution, metabolism, and excretion parameters of various drugs in the body, and compare the differences between single and combined administration.  

       Cassette PK experiments can help researchers better understand the interactions between drugs and provide important evidence for clinical medication. For example, if mutual inhibition or potentiation occurs when two drugs are used in combination, clinicians may need to adjust the dosage or regimen to ensure that patients receive treatment safely and effectively.