In Vitro ADME

        The liver is the most important organ in the body for drug metabolism and clearance, so testing the stability of compounds in hepatocytes is crucial to understand how they are metabolized in hepatocytes in vivo. Unlike microsome stability test, hepatocytes contain all hepatic enzymes involved in drug metabolism (both phase I and phase II), so hepatocyte stability test can be used to study metabolite analysis for both phase I and phase II metabolism. 

        In addition, by comparing the stability of compounds in hepatocytes of different species, it helps to understand the differences in the metabolism of compounds in distinct species.